\ STOP TASK: STOP-SIGNAL TASK
\
\ Fourth version (4.0): January 19, 2004
\ Animals are trained according to DM Eagle and TW Robbins (2003).
\ Training proceeds in four phases, several programs need input
\ individual to the animals, and provides output for the following
\ session.
\ [1] Nosepoke training
\ [2] Left lever training
\ [3] Go trials training
\ *[4] Stop-signal task *
\ Adaptation (4.1): 19 July 19, 2004
\ In this adaptation, stop-task determination is no longer based on
\ chance alone. A certain number (F) of correct go-trials must be
\ initiated before a stop-trial is presented. This adaptation was
\ made to ensure that the animals could not develop a preference
\ (for stop trials, at least).
\COMMON CODE SECOND ARRAY
^Left=1
^ExtLeft=1
^LeftExt=1
^Leftresp=1
^LeftLever=1
^Right=2
^ExtRight=2
^RightExt=2
^RightResp=2
^RightLever=2
^Tone=3
^Feeder=4
^Magazine=4
^LeftLight=5
^Middlelight=6
^Centrelight=6
^MagazineLight=6
^RightLight=7
^Houselight=8
\End common code
\Z-pulses
^StartSession=1 \Start session
^ES=2 \End session
^ST=3 \Start trial
^Stop=4 \Stop trial
^Go=5 \Go trial
^Leftpress=6 \Left lever press
^Rightpress=7 \Right lever press
^Reward=8 \Reward
^OmissionLeft=11\Omission left lever
^OmissionRight=12\Omission right lever
^EarlyResponse=13\Response before the tone is presented
\Independents
DIM A=7
VAR_ALIAS Maximum duration = A(0)
VAR_ALIAS Maximum trials = A(1)
VAR_ALIAS Inter-trial interval = A(2)
VAR_ALIAS Left lever extension time = A(3)
VAR_ALIAS Timeout time = A(4)
VAR_ALIAS Right lever extension time go trials (LHgo) = A(5) \Define from macro
VAR_ALIAS Right lever extension time stop trials (LHstop)= A(6) \Define from macro
VAR_ALIAS Tone duration = A(7)
LIST B=0.10", 0.12", 0.14", 0.16", 0.18", 0.2"
VAR_ALIAS Additional time on A(5) to add to mRT of previous day = B(0)
LIST Z=0, 0, 0, 0, 0, 0, 0, 1, 1
VAR_ALIAS Frequency of stop trials = Z(0)
LIST F=1, 1, 2, 2, 2, 2, 3, 3
VAR_ALIAS Frequency to stop trials expressed as ratio to succesful go-trials = F(0)
VAR_ALIAS Go-trials downcounter = E
LIST S=50, 0.9, 0.8, 0.7, 0.6
VAR_ALIAS Stop signal presentation times relative to mRT = S(0)
LIST U=0, 1, 2, 3, 4
\Dependents
DIM O=1
\Per C-value (per presented initiating lever)
DIM I=1000
VAR_ALIAS Time of presentation of lever=I(0)
DIM T=1000
VAR_ALIAS Speed of response=T(0)
DIM X=1000
VAR_ALIAS Chosen stop signal delay = X(0)
DIM Y=1000
VAR_ALIAS Response outcome time = Y(0) \Time to make a response on the right lever,
\will be -1 if correct stop trial
\Per S-value (per SS-delay)
DIM P=20
VAR_ALIAS Response outcome time per S-value (stop signal delay) = P(0)
VAR_ALIAS Response outcome time for go-trials = P(20) /-1 in case of an omission
DIM N=20
VAR_ALIAS Number of presentations of S-value (stop signal delay) = N(0)
DIM W=20
VAR_ALIAS Response times per S-value = W(0)
VAR_ALIAS Response times for go-trials = W(20)
VAR_ALIAS Number of go-trials = N(20)
VAR_ALIAS Total response time for mean GO trials = K
VAR_ALIAS Rewards=R
VAR_ALIAS Duration=D
VAR_ALIAS Right lever presentation counter = C
VAR_ALIAS Omission left = O(0)
VAR_ALIAS Omission right = O(1)
VAR_ALIAS Number of Go-trials to be replaced by Nogo trials because the rat responded befor ethe tone = V
\Temporary variables (used in same or next state)
DIM Q=6
VAR_ALIAS Is the tone presented yet = Q(4)
VAR_ALIAS Tone presentation greater than 0.01 = Q(5)
S.S.1,
\Basic logic
S1,
A(2)#T: SET A(0)=60;
SET A(1)=200;
SET A(2)=10; \*1"
SET A(3)=60; \*1"
SET A(4)=5; \*1"
SET A(5)=5; \*1" LHgo from macro
SET A(6)=1; \*1" LHstop from macro
SET A(7)=0.4 ---> S25 \*1"
S25,
#START: SET A(2)=A(2)*1";
SET A(3)=A(3)*1";
SET A(4)=A(4)*1";
SET A(5)=A(5)*1";
SET A(6)=A(6)*1";
SET A(7)=A(7)*1";
SET S(0)=S(0)*1";
SET S(1)=S(1)*1";
SET S(2)=S(2)*1";
SET S(3)=S(3)*1";
SET S(4)=S(4)*1";
RANDD E=F; \Determine stop-trial countdown
ON^HouseLight;
Z^StartSession ---> S2
S2,
A(2)#T: ON^LeftLight,^LeftExt ---> S3
S3, \Left response [1]
#R^Left: Z^LeftLever;
OFF^LeftExt,^LeftLight;
ON^RightExt,^RightLight;
ADD C;
SET I(C)=D; \For each presentation of the right lever, a session time
RANDD Q(0)=Z; \Legacy of previous stop-trial determination routine
RANDD Q(2)=B;
RANDD Q(1)=U; \Q1 contains a digit from 1-8, indicating the chosen SS-delay
SET X(C)=Q(1); \For each presentation, the chosen stop signal delay
\IF Q(0)=1 [@Truestop, @Falsego] \Legacy of previous stop-trial determination routine
IF E=0 [@Truestop, @Falsego]
@Truestop: RANDD E=F; \Determine new stop-trial countdown
Z^Stop;
SET X(C)=S(Q(1));
ADD N(Q(1)); \Total go trials
SHOW 5,Stop,S(Q(1))---> S5
@Falsego: IF V>0 [@TrueMakeThisStop,@FalseKeepItGo]
@TrueMakeItStop: SUB V;
Z^Stop;
SET X(C)=S(Q(1));
ADD N(Q(1)); \Total go trials
SHOW 5,Stop,S(Q(1))---> S5
@FalseKeepItGo: Z^Go;
SET X(C)=-1;
ADD N(20); \Total # of nogo trial per ss
SHOW 5,Go,0---> S4
A(3)#T: OFF^LeftLight;
OFF^HouseLight;
OFF^LeftExt;
Z^OmissionLeft;
ADD O(0) ---> S20
S4, \Right response, go trial [2a]
#R^Right: Z^RightLever; \Correct
SUB E; \New stop-trial determination routine, substract if correct go
ADD P(20); \If correct, add to P
SET K=K+T(C);
SET W(20)=W(20)+T(C);
Z^Reward;
OFF ^RightExt,^RightLight;
IF C>=A(1) [@TrueStop; @FalseCont]
@TrueStop: Z^ES ---> S10
@FalseCont: ---> S2
(A(5)+Q(2))#T: OFF^RightLight;
SET W(20)=-1;
OFF^HouseLight;
OFF^RightExt;
Z^OmissionRight;
IF C>=A(1) [@TrueStop; @FalseCont]
@TrueStop: Z^ES ---> S10
@FalseCont: ---> S20
S5, \Right response, stop trial [2b]
#R^Right: IF Q(4)=0 [@TrueToneNotPresented,@FalseTrueNogoTrial]
@TrueToneNotPresentedYet: Z13;
SET X(C)=-1;
ADD V;
ADD N(20); \Total # of nogo trial per ss, which is a go trial retrospectively
SUB N(Q(1)); \Since the tone was not presented, this was no stop-trial
SHOW 5,Corrected Go,0;
Z^RightLever; \Correct
ADD P(20); \If correct, add to P
SET K=K+T(C);
SET W(20)=W(20)+T(C);
Z^Reward;
OFF ^RightExt,^RightLight;
IF C>=A(1) [@TrueStop; @FalseCont]
@TrueStop: Z^ES ---> S10
@FalseCont: ---> S2
@FalseTrueNogoTrial: Z^RightLever;
OFF ^RightExt,^RightLight,^HouseLight;
SET W(Q(1))=W(Q(1))+T(C);
IF C>=A(1) [@TrueStop; @FalseCont]
@TrueStop: Z^ES ---> S10
@FalseCont: ---> S20
(A(6)+Q(2))#T: OFF^RightLight;
Z^Reward,^OmissionRight;
ADD P(Q(1)); \Add in case of correct only
OFF^RightExt;
IF C>=A(1) [@TrueStop; @FalseCont]
@TrueStop: Z^ES ---> S10
@FalseCont: ---> S2
S20, \TimeOut
A(4)#T: ON^HouseLight ---> S21
S21,
#R^Feeder ---> S2
S10,
A(3)#T: OFF^HouseLight;
SET I(R+1)=-987.987;
SET T(C+1)=-987.987;
SHOW 2, %Cor Go, P(20)/N(20)*100;
SHOW 3, %Cor Nogo, (P(0)+P(1)+P(2)+P(3)+P(4)+P(5)+P(6)+P(7))/(N(0)+N(1)+N(2)+N(3)+N(4)+N(5)+N(6)+N(7))*100;
SHOW 5, Trials, C---> STOPABORTFLUSH
S.S.2,
\Rewards
S1,
#Z^Reward: ON^CentreLight,^Feeder; ADD R---> S2
S2,
#R^Feeder: OFF^CentreLight,^Feeder ---> S1
S.S.3,
\Stop signal presentation
S1,
#Z^Stop: SET Q(4)=0; SET Q(5)=A(6)-S(Q(1)); IF Q(5)<0.01 [@Smaller, @OK]
@Smaller: SET Q(5)=0.01 ---> S2
@OK: ---> S2
S2,
#Z13: ---> S3
Q(5)#T: ON^Tone; ADD Q(4) ---> S3
\ A(6)-S(Q(1))#T: ON^Tone; ADD Q(4) ---> S3
S3,
A(7)#T: OFF^Tone ---> S1
S.S.10,
\Timers
S1,
#Z^StartSession: ---> S2
S2,
0.1": SET D=D+0.1; IF D>(A(0)*60) [@TrueStop, @FalseContinue]
@TrueStop: Z^ES;
OFF^HouseLight;
SET I(C+1)=-987.987;
SET T(C+1)=-987.987;
SHOW 2, %Cor Go, P(20)/N(20)*100;
SHOW 3, %Cor Nogo, (P(0)+P(1)+P(2)+P(3)+P(4)+P(5)+P(6)+P(7))/(N(0)+N(1)+N(2)+N(3)+N(4)+N(5)+N(6)+N(7))*100 ;
SHOW 5, Trials, C ---> STOPABORTFLUSH
@FalseContinue: ---> S2
S.S.11,
S1,
#Z^LeftLever: ---> S2
S2,
#Z^RightLever: ---> S1
#Z^OmissionRight: SET T(C)=-1 ---> S1
0.01": SET T(C)=T(C)+0.01 ---> S2
S.S.20,
\Screen writer
S1,
#Z^StartSession: ---> S2
S2,
.1": SHOW 1, Duration, D/60;
SHOW 2, Rewards, R;
SHOW 4, mRT-GO,K/(P(20)+.000000001);
\SHOW 4, maxRT GO, A(5)+Q(2);
SHOW 3, Trials, C;
\SHOW 5, maxRT NOGO, A(6)+Q(2);
SHOW 6, IRT, I(R);
SHOW 7, OmLeft, O(0);
SHOW 8, OmRght, O(1);
SHOW 9, prev mRT GO, A(5);
SHOW 10, prev mRT NOGO, A(6);
SHOW 11, #Go, N(20);
SHOW 12, #Cor go, P(20);
SHOW 13, Countdown, E;
SHOW 15, Ratio, ((N(0)+N(1)+N(2)+N(3)+N(4)+N(5)+N(6)+N(7))/(N(20)+.00000001));
SHOW 16, #Nogo 0, N(0);
SHOW 17, #Cor nogo 0, P(0);
SHOW 18, #Nogo 0 time, S(0);
SHOW 21, #Nogo 1, N(1);
SHOW 22, #Cor nogo 1, P(1);
SHOW 23, #Nogo 1 time, S(1);
SHOW 26, #Nogo 2, N(2);
SHOW 27, #Cor nogo 2, P(2);
SHOW 28, #Nogo 2 time, S(2);
SHOW 31, #Nogo 3, N(3);
SHOW 32, #Cor nogo 3, P(3);
SHOW 33, #Nogo 3 time, S(3);
SHOW 36, #Nogo 4, N(4);
SHOW 37, #Cor nogo 4, P(4);
SHOW 38, #Nogo 4 time, S(4)---> S2
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